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1bgq

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{{STRUCTURE_1bgq| PDB=1bgq | SCENE= }}
{{STRUCTURE_1bgq| PDB=1bgq | SCENE= }}
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'''RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE'''
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===RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE===
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==Overview==
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The cellular activity of several regulatory and signal transduction proteins, which depend on the Hsp90 molecular chaperone for folding, is markedly decreased by geldanamycin and by radicicol (monorden). We now show that these unrelated compounds both bind to the N-terminal ATP/ADP-binding domain of Hsp90, with radicicol displaying nanomolar affinity, and both inhibit the inherent ATPase activity of Hsp90 which is essential for its function in vivo. Crystal structure determinations of Hsp90 N-terminal domain complexes with geldanamycin and radicicol identify key aspects of their nucleotide mimicry and suggest a rational basis for the design of novel antichaperone drugs.
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(as it appears on PubMed at http://www.pubmed.gov), where 9925731 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9925731}}
==About this Structure==
==About this Structure==
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[[Category: Heat shock]]
[[Category: Heat shock]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
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Revision as of 16:07, 30 June 2008

Image:1bgq.png

Template:STRUCTURE 1bgq

RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE

Template:ABSTRACT PUBMED 9925731

About this Structure

1BGQ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin., Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH, J Med Chem. 1999 Jan 28;42(2):260-6. PMID:9925731

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