1bk6

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{{STRUCTURE_1bk6| PDB=1bk6 | SCENE= }}
{{STRUCTURE_1bk6| PDB=1bk6 | SCENE= }}
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'''KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS'''
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===KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS===
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==Overview==
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Selective nuclear import is mediated by nuclear localization signals (NLSs) and cognate transport factors known as karyopherins or importins. Karyopherin alpha recognizes "classical" monopartite and bipartite NLSs. We report the crystal structure of a 50 kDa fragment of the 60 kDa yeast karyopherin alpha, in the absence and presence of a monopartite NLS peptide at 2.2 A and 2.8 A resolution, respectively. The structure shows a tandem array of ten armadillo repeats, organized in a right-handed superhelix of helices. Binding of the NLS peptide occurs at two sites within a helical surface groove that is lined by conserved residues. The structure reveals the determinants of NLS specificity and suggests a model for the recognition of bipartite NLSs.
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(as it appears on PubMed at http://www.pubmed.gov), where 9695948 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9695948}}
==About this Structure==
==About this Structure==
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[[Category: Nls nuclear import]]
[[Category: Nls nuclear import]]
[[Category: Protein transport]]
[[Category: Protein transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:37:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:17:46 2008''

Revision as of 16:17, 30 June 2008

Image:1bk6.png

Template:STRUCTURE 1bk6

KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS

Template:ABSTRACT PUBMED 9695948

About this Structure

1BK6 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha., Conti E, Uy M, Leighton L, Blobel G, Kuriyan J, Cell. 1998 Jul 24;94(2):193-204. PMID:9695948

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