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1bv4

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[[Image:1bv4.gif|left|200px]]
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{{STRUCTURE_1bv4| PDB=1bv4 | SCENE= }}
{{STRUCTURE_1bv4| PDB=1bv4 | SCENE= }}
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'''APO-MANNOSE-BINDING PROTEIN-C'''
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===APO-MANNOSE-BINDING PROTEIN-C===
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==Overview==
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C-type animal lectins are a diverse family of proteins which mediate cell-surface carbohydrate-recognition events through a conserved carbohydrate-recognition domain (CRD). Most members of this family possess a carbohydrate-binding activity that depends strictly on the binding of Ca2+ at two sites, designated 1 and 2, in the CRD. The structural transitions associated with Ca2+ binding in C-type lectins have been investigated by determining high-resolution crystal structures of rat serum mannose-binding protein (MBP) bound to one Ho3+ in place of Ca2+, and the apo form of rat liver MBP. The removal of Ca2+ does not affect the core structure of the CRD, but dramatic conformational changes occur in the loops. The most significant structural change in the absence of Ca2+ is the isomerization of a cis-peptide bond preceding a conserved proline residue in Ca2+ site 2. This bond adopts the cis conformation in all Ca2+-bound structures, whereas both cis and trans conformations are observed in the absence of Ca2+. The pattern of structural changes in the three loops that interact with Ca2+ is dictated in large part by the conformation of the prolyl peptide bond. The highly conserved nature of Ca2+ site 2 suggests that the transitions observed in MBPs are general features of Ca2+ binding in C-type lectins.
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The line below this paragraph, {{ABSTRACT_PUBMED_9922165}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9922165 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9922165}}
==About this Structure==
==About this Structure==
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[[Category: Calcium-binding protein]]
[[Category: Calcium-binding protein]]
[[Category: Collectin]]
[[Category: Collectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:59:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:46:02 2008''

Revision as of 16:46, 30 June 2008

Image:1bv4.png

Template:STRUCTURE 1bv4

APO-MANNOSE-BINDING PROTEIN-C

Template:ABSTRACT PUBMED 9922165

About this Structure

1BV4 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Ca2+-dependent structural changes in C-type mannose-binding proteins., Ng KK, Park-Snyder S, Weis WI, Biochemistry. 1998 Dec 22;37(51):17965-76. PMID:9922165

Page seeded by OCA on Mon Jun 30 19:46:02 2008

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