1bwm

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[[Image:1bwm.gif|left|200px]]
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{{STRUCTURE_1bwm| PDB=1bwm | SCENE= }}
{{STRUCTURE_1bwm| PDB=1bwm | SCENE= }}
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'''A SINGLE-CHAIN T CELL RECEPTOR'''
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===A SINGLE-CHAIN T CELL RECEPTOR===
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==Overview==
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Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.
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The line below this paragraph, {{ABSTRACT_PUBMED_10360364}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10360364 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10360364}}
==About this Structure==
==About this Structure==
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1BWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA].
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1BWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA].
==Reference==
==Reference==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Immunoreceptor]]
[[Category: Immunoreceptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:02:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:49:58 2008''

Revision as of 16:49, 30 June 2008

Image:1bwm.png

Template:STRUCTURE 1bwm

A SINGLE-CHAIN T CELL RECEPTOR

Template:ABSTRACT PUBMED 10360364

About this Structure

1BWM is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor., Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G, Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:10360364

Page seeded by OCA on Mon Jun 30 19:49:58 2008

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