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1c44

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{{STRUCTURE_1c44| PDB=1c44 | SCENE= }}
{{STRUCTURE_1c44| PDB=1c44 | SCENE= }}
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'''STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT'''
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===STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT===
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==Overview==
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Sterol carrier protein 2, also known as nonspecific lipid transfer protein is a ubiquitous, small, basic protein of 13 kDa found in animals. Its primary structure is highly conserved between different species, and it has been implicated in the intracellular transport of lipids and in a wide range of other in vitro functions related to sterol and fatty acid metabolism. Sterol carrier protein 2 deficiency in mice leads to elevated concentrations of phytanic acid in the serum and causes hepatocarcinogenesis. However, its actual physiological role is still unknown. Although sterol carrier protein 2 has been studied extensively in the past 20 years, very little is known concerning its three-dimensional structure. The crystal structure of rabbit sterol carrier protein 2, determined at 1.8 A resolution with the MIRAS method, shows a unique alpha/beta-fold. The core of this protein forms a five-stranded antiparallel beta-sheet flanked by five helices. A C-terminal segment (residues 114-123), together with part of the beta-sheet and four alpha-helices, form a hydrophobic tunnel providing the environment for apolar ligands such as fatty acids and fatty acyl-coenzyme As. Structurally well-characterized nonspecific lipid transfer proteins from plants have hydrophobic tunnel-like cavities, which were identified as the binding site for fatty acids and related apolar ligands. Despite the fact that plant nonspecific lipid transfer proteins are smaller proteins than sterol carrier protein 2, show no sequence homology to sterol carrier protein 2, and are structurally unrelated, the cavities of these two classes of proteins are very similar with respect to size, shape, and hydrophobicity, suggesting a common functional role.
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(as it appears on PubMed at http://www.pubmed.gov), where 10684638 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10684638}}
==About this Structure==
==About this Structure==
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[[Category: Non specific lipid transfer protein]]
[[Category: Non specific lipid transfer protein]]
[[Category: Sterol carrier protein]]
[[Category: Sterol carrier protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:18:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:11:05 2008''

Revision as of 17:11, 30 June 2008

Image:1c44.png

Template:STRUCTURE 1c44

STEROL CARRIER PROTEIN 2 (SCP2) FROM RABBIT

Template:ABSTRACT PUBMED 10684638

About this Structure

1C44 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structure of sterol carrier protein 2 at 1.8 A resolution reveals a hydrophobic tunnel suitable for lipid binding., Choinowski T, Hauser H, Piontek K, Biochemistry. 2000 Feb 29;39(8):1897-902. PMID:10684638

Page seeded by OCA on Mon Jun 30 20:11:05 2008

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