This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1c4l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1c4l.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1c4l.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1c4l| PDB=1c4l | SCENE= }}
{{STRUCTURE_1c4l| PDB=1c4l | SCENE= }}
-
'''SOLUTION STRUCTURE OF AN RNA DUPLEX INCLUDING A C-U BASE-PAIR'''
+
===SOLUTION STRUCTURE OF AN RNA DUPLEX INCLUDING A C-U BASE-PAIR===
-
==Overview==
+
<!--
-
The formation of the C-U base pair in a duplex was observed in solution by means of the temperature profile of (15)N chemical shifts, and the precise geometry of the C-U base pair was also determined by NOE-based structure calculation. From the solution structure of the RNA oligomer, r[CGACUCAGG].r[CCUGCGUCG], it was found that a single C-U mismatch preferred being stacked in the duplex rather than being flipped-out even in solution. Moreover, it adopts an irregular geometry, where the amino nitrogen (N4) of the cytidine and keto-oxygen (O4) of the uridine are within hydrogen-bonding distance, as seen in crystals. To further prove the presence of a hydrogen bond in the C-U pair, we employed a point-labeled cytidine at the exocyclic amino nitrogen of the cytidine in the C-U pair. The temperature profile of its (15)N chemical shift showed a sigmoidal transition curve, indicating the presence of a hydrogen bond in the C-U pair in the duplex.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10852704}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10852704 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10852704}}
==About this Structure==
==About this Structure==
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4L OCA].
+
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4L OCA].
==Reference==
==Reference==
Line 31: Line 35:
[[Category: Yasuno, K.]]
[[Category: Yasuno, K.]]
[[Category: C-u base pair]]
[[Category: C-u base pair]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:19:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:12:03 2008''

Revision as of 17:12, 30 June 2008

Image:1c4l.png

Template:STRUCTURE 1c4l

SOLUTION STRUCTURE OF AN RNA DUPLEX INCLUDING A C-U BASE-PAIR

Template:ABSTRACT PUBMED 10852704

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of an RNA duplex including a C-U base pair., Tanaka Y, Kojima C, Yamazaki T, Kodama TS, Yasuno K, Miyashita S, Ono A, Ono A, Kainosho M, Kyogoku Y, Biochemistry. 2000 Jun 20;39(24):7074-80. PMID:10852704

Page seeded by OCA on Mon Jun 30 20:12:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1c4l"
Personal tools