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1c7y

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[[Image:1c7y.gif|left|200px]]
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{{STRUCTURE_1c7y| PDB=1c7y | SCENE= }}
{{STRUCTURE_1c7y| PDB=1c7y | SCENE= }}
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'''E.COLI RUVA-HOLLIDAY JUNCTION COMPLEX'''
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===E.COLI RUVA-HOLLIDAY JUNCTION COMPLEX===
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==Overview==
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In the major pathway of homologous DNA recombination in prokaryotic cells, the Holliday junction intermediate is processed through its association with RuvA, RuvB, and RuvC proteins. Specific binding of the RuvA tetramer to the Holliday junction is required for the RuvB motor protein to be loaded onto the junction DNA, and the RuvAB complex drives the ATP-dependent branch migration. We solved the crystal structure of the Holliday junction bound to a single Escherichia coli RuvA tetramer at 3.1-A resolution. In this complex, one side of DNA is accessible for cleavage by RuvC resolvase at the junction center. The refined junction DNA structure revealed an open concave architecture with a four-fold symmetry. Each arm, with B-form DNA, in the Holliday junction is predominantly recognized in the minor groove through hydrogen bonds with two repeated helix-hairpin-helix motifs of each RuvA subunit. The local conformation near the crossover point, where two base pairs are disrupted, suggests a possible scheme for successive base pair rearrangements, which may account for smooth Holliday junction movement without segmental unwinding.
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The line below this paragraph, {{ABSTRACT_PUBMED_10890893}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10890893 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10890893}}
==About this Structure==
==About this Structure==
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[[Category: Homologous recombination]]
[[Category: Homologous recombination]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:26:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:20:22 2008''

Revision as of 17:20, 30 June 2008

Image:1c7y.png

Template:STRUCTURE 1c7y

E.COLI RUVA-HOLLIDAY JUNCTION COMPLEX

Template:ABSTRACT PUBMED 10890893

About this Structure

1C7Y is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the holliday junction DNA in complex with a single RuvA tetramer., Ariyoshi M, Nishino T, Iwasaki H, Shinagawa H, Morikawa K, Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8257-62. PMID:10890893

Page seeded by OCA on Mon Jun 30 20:20:22 2008

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