This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1caz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1caz.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1caz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1caz| PDB=1caz | SCENE= }}
{{STRUCTURE_1caz| PDB=1caz | SCENE= }}
-
'''WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE'''
+
===WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE===
-
==Overview==
+
<!--
-
The molecular structures of the acetate complexes of wild-type human carbonic anhydrase II (HCAII) and of E106Q mutant human carbonic anhydrase II were solved with high completeness (89-91%) to 2.1 and 1.9 A resolution, respectively. Both wild-type and mutant enzyme crystallize in space group P2(1) with cell dimensions a = 42.7, b = 41.7, c = 73.0 A and beta = 104.6 degrees. The altered active-site hydrogen-bond network caused by the mutation results in a different binding of the inhibitor in the two complexes. In the mutant, but not in the wild-type complex, a carboxylate O atom is within hydrogen-bond distance of Thr199 Ogamma1. In the wild-type enzyme ligand hydrogen bonding to this atom is normally only found for hydrogen-bond donors. The importance of this discrimination on catalysis by the enzyme is discussed briefly.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15299482}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15299482 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15299482}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Xue, Y.]]
[[Category: Xue, Y.]]
[[Category: Zaitsev, V.]]
[[Category: Zaitsev, V.]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:32:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:29:41 2008''

Revision as of 17:29, 30 June 2008

Image:1caz.png

Template:STRUCTURE 1caz

WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE

Template:ABSTRACT PUBMED 15299482

About this Structure

1CAZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Wild-type and E106Q mutant carbonic anhydrase complexed with acetate., Hakansson K, Briand C, Zaitsev V, Xue Y, Liljas A, Acta Crystallogr D Biol Crystallogr. 1994 Jan 1;50(Pt 1):101-4. PMID:15299482

Page seeded by OCA on Mon Jun 30 20:29:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1caz"
Personal tools