1cdd

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[[Image:1cdd.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1cdd| PDB=1cdd | SCENE= }}
{{STRUCTURE_1cdd| PDB=1cdd | SCENE= }}
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'''STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE'''
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===STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE===
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==Overview==
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The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design.
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(as it appears on PubMed at http://www.pubmed.gov), where 1631098 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1631098}}
==About this Structure==
==About this Structure==
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[[Category: Janson, C A.]]
[[Category: Janson, C A.]]
[[Category: Kan, C C.]]
[[Category: Kan, C C.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:36:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:35:14 2008''

Revision as of 17:35, 30 June 2008

Image:1cdd.png

Template:STRUCTURE 1cdd

STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE

Template:ABSTRACT PUBMED 1631098

About this Structure

1CDD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:1631098

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