1cdl

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[[Image:1cdl.gif|left|200px]]
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{{STRUCTURE_1cdl| PDB=1cdl | SCENE= }}
{{STRUCTURE_1cdl| PDB=1cdl | SCENE= }}
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'''TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX'''
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===TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX===
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==Overview==
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The crystal structure of calcium-bound calmodulin (Ca(2+)-CaM) bound to a peptide analog of the CaM-binding region of chicken smooth muscle myosin light chain kinase has been determined and refined to a resolution of 2.4 angstroms (A). The structure is compact and has the shape of an ellipsoid (axial ratio approximately 2:1). The bound CaM forms a tunnel diagonal to its long axis that engulfs the helical peptide, with the hydrophobic regions of CaM melded into a single area that closely covers the hydrophobic side of the peptide. There is a remarkably high pseudo-twofold symmetry between the closely associated domains. The central helix of the native CaM is unwound and expanded into a bend between residues 73 and 77. About 185 contacts (less than 4 A) are formed between CaM and the peptide, with van der Waals contacts comprising approximately 80% of this total.
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(as it appears on PubMed at http://www.pubmed.gov), where 1519061 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1519061}}
==About this Structure==
==About this Structure==
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[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
[[Category: Calcium-binding protein]]
[[Category: Calcium-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:36:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:35:55 2008''

Revision as of 17:35, 30 June 2008

Image:1cdl.png

Template:STRUCTURE 1cdl

TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX

Template:ABSTRACT PUBMED 1519061

About this Structure

1CDL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex., Meador WE, Means AR, Quiocho FA, Science. 1992 Aug 28;257(5074):1251-5. PMID:1519061

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