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1cei

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{{STRUCTURE_1cei| PDB=1cei | SCENE= }}
{{STRUCTURE_1cei| PDB=1cei | SCENE= }}
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'''STRUCTURE DETERMINATION OF THE COLICIN E7 IMMUNITY PROTEIN (IMME7) THAT BINDS SPECIFICALLY TO THE DNASE-TYPE COLICIN E7 AND INHIBITS ITS BACTERIOCIDAL ACTIVITY'''
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===STRUCTURE DETERMINATION OF THE COLICIN E7 IMMUNITY PROTEIN (IMME7) THAT BINDS SPECIFICALLY TO THE DNASE-TYPE COLICIN E7 AND INHIBITS ITS BACTERIOCIDAL ACTIVITY===
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==Overview==
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The immunity protein of colicin E7 (ImmE7) can bind specifically to the DNase-type colicin E7 and inhibit its bactericidal activity. Here we report the 1.8-angstrom crystal structure of the ImmE7 protein. This is the first x-ray structure determined in the superfamily of colicin immunity proteins. The ImmE7 protein consists of four antiparallel alpha-helices, folded in a topology similar to the architecture of a four-helix bundle structure. A region rich in acidic residues is identified. This negatively charged area has the greatest variability within the family of DNase-type immunity proteins; thus, it seems likely that this area is involved in specific binding to colicin. Based on structural, genetic, and kinetic data, we suggest that all the DNase-type immunity proteins, as well as colicins, share a "homologous-structural framework" and that specific interaction between a colicin and its cognate immunity protein relies upon how well these two proteins' charged residues match on the interaction surface, thus leading to specific immunity of the colicin.
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(as it appears on PubMed at http://www.pubmed.gov), where 8692833 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8692833}}
==About this Structure==
==About this Structure==
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[[Category: Yuan, H S.]]
[[Category: Yuan, H S.]]
[[Category: Immunity protein]]
[[Category: Immunity protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:38:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:38:16 2008''

Revision as of 17:38, 30 June 2008

Image:1cei.png

Template:STRUCTURE 1cei

STRUCTURE DETERMINATION OF THE COLICIN E7 IMMUNITY PROTEIN (IMME7) THAT BINDS SPECIFICALLY TO THE DNASE-TYPE COLICIN E7 AND INHIBITS ITS BACTERIOCIDAL ACTIVITY

Template:ABSTRACT PUBMED 8692833

About this Structure

1CEI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The crystal structure of the immunity protein of colicin E7 suggests a possible colicin-interacting surface., Chak KF, Safo MK, Ku WY, Hsieh SY, Yuan HS, Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6437-42. PMID:8692833

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