1cii

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[[Image:1cii.gif|left|200px]]
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{{STRUCTURE_1cii| PDB=1cii | SCENE= }}
{{STRUCTURE_1cii| PDB=1cii | SCENE= }}
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'''COLICIN IA'''
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===COLICIN IA===
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==Overview==
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The ion-channel forming colicins A, B, E1, Ia, Ib and N all kill bacterial cells selectively by co-opting bacterial active-transport pathways and forming voltage-gated ion conducting channels across the plasma membrane of the target bacterium. The crystal structure of colicin Ia reveals a molecule 210 A long with three distinct functional domains arranged along a backbone of two extraordinarily long alpha-helices. A central domain at the bend of the hairpin-like structure mediates specific recognition and binding to an outer-membrane receptor. A second domain mediates translocation across the outer membrane via the TonB transport pathway; the TonB-box recognition element of colicin Ia is on one side of three 80 A-long helices arranged as a helical sheet. A third domain is made up of 10 alpha-helices which form a voltage-activated and voltage-gated ion conducting channel across the plasma membrane of the target cell. The two 160 A-long alpha-helices that link the receptor-binding domain to the other domains enable the colicin Ia molecule to span the periplasmic space and contact both the outer and plasma membranes simultaneously during function.
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(as it appears on PubMed at http://www.pubmed.gov), where 9009197 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9009197}}
==About this Structure==
==About this Structure==
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[[Category: Ion channel formation]]
[[Category: Ion channel formation]]
[[Category: Transmembrane protein]]
[[Category: Transmembrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:46:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:47:31 2008''

Revision as of 17:47, 30 June 2008

Image:1cii.png

Template:STRUCTURE 1cii

COLICIN IA

Template:ABSTRACT PUBMED 9009197

About this Structure

1CII is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of colicin Ia., Wiener M, Freymann D, Ghosh P, Stroud RM, Nature. 1997 Jan 30;385(6615):461-4. PMID:9009197

Page seeded by OCA on Mon Jun 30 20:47:31 2008

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