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1cmx

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[[Image:1cmx.gif|left|200px]]
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{{Seed}}
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[[Image:1cmx.png|left|200px]]
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{{STRUCTURE_1cmx| PDB=1cmx | SCENE= }}
{{STRUCTURE_1cmx| PDB=1cmx | SCENE= }}
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'''STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES'''
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===STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES===
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==Overview==
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The release of ubiquitin from attachment to other proteins and adducts is critical for ubiquitin biosynthesis, proteasomal degradation and other cellular processes. De-ubiquitination is accomplished in part by members of the UCH (ubiquitin C-terminal hydrolase) family of enzymes. We have determined the 2.25 A resolution crystal structure of the yeast UCH, Yuh1, in a complex with the inhibitor ubiquitin aldehyde (Ubal). The structure mimics the tetrahedral intermediate in the reaction pathway and explains the very high enzyme specificity. Comparison with a related, unliganded UCH structure indicates that ubiquitin binding is coupled to rearrangements which block the active-site cleft in the absence of authentic substrate. Remarkably, a 21-residue loop that becomes ordered upon binding Ubal lies directly over the active site. Efficiently processed substrates apparently pass through this loop, and constraints on the loop conformation probably function to control UCH specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 10406793 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10406793}}
==About this Structure==
==About this Structure==
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[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin hydrolase]]
[[Category: Ubiquitin hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:54:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:58:04 2008''

Revision as of 17:58, 30 June 2008

Image:1cmx.png

Template:STRUCTURE 1cmx

STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES

Template:ABSTRACT PUBMED 10406793

About this Structure

1CMX is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

Structural basis for the specificity of ubiquitin C-terminal hydrolases., Johnston SC, Riddle SM, Cohen RE, Hill CP, EMBO J. 1999 Jul 15;18(14):3877-87. PMID:10406793

Page seeded by OCA on Mon Jun 30 20:58:04 2008

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