1ctr

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[[Image:1ctr.jpg|left|200px]]
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{{STRUCTURE_1ctr| PDB=1ctr | SCENE= }}
{{STRUCTURE_1ctr| PDB=1ctr | SCENE= }}
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'''DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX'''
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===DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX===
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==Overview==
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The crystal structure of calmodulin (CaM) bound to trifluoperazine (TFP) has been determined and refined to a resolution of 2.45 A. Only one TFP is bound to CaM, but that is sufficient to cause distortion of the central alpha-helix and juxtaposition of the N- and C-terminal domains similar to that seen in CaM-polypeptide complexes. The drug makes extensive contacts with residues in the C-terminal domain of CaM but only a few contacts with one residue in the N-terminal domain. The structure suggests that substrate binding to the C-terminal domain is sufficient to cause the conformational changes in calmodulin that lead to activation of its targets.
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The line below this paragraph, {{ABSTRACT_PUBMED_7803388}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7803388 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7803388}}
==About this Structure==
==About this Structure==
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[[Category: Walter, M R.]]
[[Category: Walter, M R.]]
[[Category: Calcium-binding protein]]
[[Category: Calcium-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:06:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:21:32 2008''

Revision as of 18:21, 30 June 2008

Image:1ctr.png

Template:STRUCTURE 1ctr

DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX

Template:ABSTRACT PUBMED 7803388

About this Structure

1CTR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex., Cook WJ, Walter LJ, Walter MR, Biochemistry. 1994 Dec 27;33(51):15259-65. PMID:7803388

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