1cz0

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[[Image:1cz0.gif|left|200px]]
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{{STRUCTURE_1cz0| PDB=1cz0 | SCENE= }}
{{STRUCTURE_1cz0| PDB=1cz0 | SCENE= }}
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'''INTRON ENCODED HOMING ENDONUCLEASE I-PPOI/DNA COMPLEX LACKING CATALYTIC METAL ION'''
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===INTRON ENCODED HOMING ENDONUCLEASE I-PPOI/DNA COMPLEX LACKING CATALYTIC METAL ION===
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==Overview==
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A novel mechanism of DNA endonucleolytic cleavage has been visualized for the homing endonuclease I-PpoI by trapping the uncleaved enzyme-substrate complex and comparing it to the previously visualized product complex. This enzyme employs a unique single metal mechanism. A magnesium ion is coordinated by an asparagine residue and two DNA oxygen atoms and stabilizes the phosphoanion transition state and the 3'oxygen leaving group. A hydrolytic water molecule is activated by a histidine residue for an in-line attack on the scissile phosphate. A strained enzyme-substrate-metal complex is formed before cleavage, then relaxed during the reaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 10581547 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10581547}}
==About this Structure==
==About this Structure==
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[[Category: His-cys box zinc binding site]]
[[Category: His-cys box zinc binding site]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:15:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:49:31 2008''

Revision as of 18:49, 30 June 2008

Image:1cz0.png

Template:STRUCTURE 1cz0

INTRON ENCODED HOMING ENDONUCLEASE I-PPOI/DNA COMPLEX LACKING CATALYTIC METAL ION

Template:ABSTRACT PUBMED 10581547

About this Structure

1CZ0 is a Single protein structure of sequence from Physarum polycephalum. Full crystallographic information is available from OCA.

Reference

A novel endonuclease mechanism directly visualized for I-PpoI., Galburt EA, Chevalier B, Tang W, Jurica MS, Flick KE, Monnat RJ Jr, Stoddard BL, Nat Struct Biol. 1999 Dec;6(12):1096-9. PMID:10581547

Page seeded by OCA on Mon Jun 30 21:49:31 2008

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