1d3b

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{{STRUCTURE_1d3b| PDB=1d3b | SCENE= }}
{{STRUCTURE_1d3b| PDB=1d3b | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE D3B SUBCOMPLEX OF THE HUMAN CORE SNRNP DOMAIN AT 2.0A RESOLUTION'''
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===CRYSTAL STRUCTURE OF THE D3B SUBCOMPLEX OF THE HUMAN CORE SNRNP DOMAIN AT 2.0A RESOLUTION===
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==Overview==
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The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F, and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs (snRNAs). These proteins share a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. Crystal structures of two Sm protein complexes, D3B and D1D2, show that these proteins have a common fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta sheet, and the D1D2 and D3B dimers superpose closely in their core regions, including the dimer interfaces. The crystal structures suggest that the seven Sm proteins could form a closed ring and the snRNAs may be bound in the positively charged central hole.
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{{ABSTRACT_PUBMED_10025403}}
==About this Structure==
==About this Structure==
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[[Category: Splicing]]
[[Category: Splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:17:03 2008''

Revision as of 19:17, 30 June 2008

Image:1d3b.png

Template:STRUCTURE 1d3b

CRYSTAL STRUCTURE OF THE D3B SUBCOMPLEX OF THE HUMAN CORE SNRNP DOMAIN AT 2.0A RESOLUTION

Template:ABSTRACT PUBMED 10025403

About this Structure

1D3B is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs., Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K, Cell. 1999 Feb 5;96(3):375-87. PMID:10025403

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