1d5t

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{{STRUCTURE_1d5t| PDB=1d5t | SCENE= }}
{{STRUCTURE_1d5t| PDB=1d5t | SCENE= }}
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'''GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM'''
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===GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM===
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==Overview==
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Guanine nucleotide dissociation inhibitor (GDI) is a 55-kDa protein that functions in vesicular membrane transport to recycle Rab GTPases. We have now determined the crystal structure of bovine alpha-GDI at ultra-high resolution (1.04 A). Refinement at this resolution highlighted a region with high mobility of its main-chain residues. This corresponded to a surface loop in the primarily alpha-helical domain II at the base of alpha-GDI containing the previously uncharacterized sequence-conserved region (SCR) 3A. Site-directed mutagenesis showed that this mobile loop plays a crucial role in binding of GDI to membranes and extraction of membrane-bound Rab. This domain, referred to as the mobile effector loop, in combination with Rab-binding residues found in the multi-sheet domain I at the apex of alpha-GDI may provide flexibility for recycling of diverse Rab GTPases. We propose that conserved residues in domains I and II synergize to form the functional face of GDI, and that domain II mediates a critical step in Rab recycling during vesicle fusion.
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{{ABSTRACT_PUBMED_11208110}}
==About this Structure==
==About this Structure==
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[[Category: Zeng, K.]]
[[Category: Zeng, K.]]
[[Category: Ultra-high resolution]]
[[Category: Ultra-high resolution]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:28:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:29:49 2008''

Revision as of 19:29, 30 June 2008

Image:1d5t.png

Template:STRUCTURE 1d5t

GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM

Template:ABSTRACT PUBMED 11208110

About this Structure

1D5T is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

A new functional domain of guanine nucleotide dissociation inhibitor (alpha-GDI) involved in Rab recycling., Luan P, Heine A, Zeng K, Moyer B, Greasely SE, Kuhn P, Balch WE, Wilson IA, Traffic. 2000 Mar;1(3):270-81. PMID:11208110

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