1dch

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[[Image:1dch.gif|left|200px]]
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{{STRUCTURE_1dch| PDB=1dch | SCENE= }}
{{STRUCTURE_1dch| PDB=1dch | SCENE= }}
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'''CRYSTAL STRUCTURE OF DCOH, A BIFUNCTIONAL, PROTEIN-BINDING TRANSCRIPTION COACTIVATOR'''
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===CRYSTAL STRUCTURE OF DCOH, A BIFUNCTIONAL, PROTEIN-BINDING TRANSCRIPTION COACTIVATOR===
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==Overview==
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DCoH, the dimerization cofactor of hepatocyte nuclear factor-1, stimulates gene expression by associating with specific DNA binding proteins and also catalyzes the dehydration of the biopterin cofactor of phenylalanine hydroxylase. The x-ray crystal structure determined at 3 angstrom resolution reveals that DCoH forms a tetramer containing two saddle-shaped grooves that comprise likely macromolecule binding sites. Two equivalent enzyme active sites flank each saddle, suggesting that there is a spatial connection between the catalytic and binding activities. Structural similarities between the DCoH fold and nucleic acid-binding proteins argue that the saddle motif has evolved to bind diverse ligands or that DCoH unexpectedly may bind nucleic acids.
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(as it appears on PubMed at http://www.pubmed.gov), where 7725101 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7725101}}
==About this Structure==
==About this Structure==
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[[Category: Transcriptional simulator]]
[[Category: Transcriptional simulator]]
[[Category: Transregulator of homeodomain protein]]
[[Category: Transregulator of homeodomain protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:49:18 2008''

Revision as of 19:49, 30 June 2008

Image:1dch.png

Template:STRUCTURE 1dch

CRYSTAL STRUCTURE OF DCOH, A BIFUNCTIONAL, PROTEIN-BINDING TRANSCRIPTION COACTIVATOR

Template:ABSTRACT PUBMED 7725101

About this Structure

1DCH is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator., Endrizzi JA, Cronk JD, Wang W, Crabtree GR, Alber T, Science. 1995 Apr 28;268(5210):556-9. PMID:7725101

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