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1ddm

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{{STRUCTURE_1ddm| PDB=1ddm | SCENE= }}
{{STRUCTURE_1ddm| PDB=1ddm | SCENE= }}
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'''SOLUTION STRUCTURE OF THE NUMB PTB DOMAIN COMPLEXED TO A NAK PEPTIDE'''
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===SOLUTION STRUCTURE OF THE NUMB PTB DOMAIN COMPLEXED TO A NAK PEPTIDE===
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==Overview==
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The phosphotyrosine-binding (PTB) domain of the cell fate determinant Numb is involved in the formation of multiple protein complexes in vivo and can bind a diverse array of peptide sequences in vitro. To investigate the structural basis for the promiscuous nature of this protein module, we have determined its solution structure by NMR in a complex with a peptide containing an NMSF sequence derived from the Numb-associated kinase (Nak). The Nak peptide was found to adopt a significantly different structure from that of a GPpY sequence-containing peptide previously determined. In contrast to the helical turn adopted by the GPpY peptide, the Nak peptide forms a beta-turn at the NMSF site followed by another turn near the C-terminus. The Numb PTB domain appears to recognize peptides that differ in both primary and secondary structures by engaging various amounts of the binding surface of the protein. Our results suggest a mechanism through which a single PTB domain might interact with multiple distinct target proteins to control a complex biological process such as asymmetric cell division.
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(as it appears on PubMed at http://www.pubmed.gov), where 10747019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10747019}}
==About this Structure==
==About this Structure==
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1DDM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDM OCA].
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1DDM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDM OCA].
==Reference==
==Reference==
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[[Category: Complex]]
[[Category: Complex]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:43:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:52:11 2008''

Revision as of 19:52, 30 June 2008

Image:1ddm.png

Template:STRUCTURE 1ddm

SOLUTION STRUCTURE OF THE NUMB PTB DOMAIN COMPLEXED TO A NAK PEPTIDE

Template:ABSTRACT PUBMED 10747019

About this Structure

1DDM is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb., Zwahlen C, Li SC, Kay LE, Pawson T, Forman-Kay JD, EMBO J. 2000 Apr 3;19(7):1505-15. PMID:10747019

Page seeded by OCA on Mon Jun 30 22:52:11 2008

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