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1dn6

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{{STRUCTURE_1dn6| PDB=1dn6 | SCENE= }}
{{STRUCTURE_1dn6| PDB=1dn6 | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA'''
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===THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA===
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==Overview==
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Most genes in higher organisms are activated by the binding of proteins called transcription factors. One such protein, transcription factor IIIA (TFIIIA) from the frog, activates the gene for 5S RNA by binding to the region of the gene between nucleotides 45 and 97. This binding site has been defined by a variety of biochemical studies, including base-deletion experiments and DNase I footprinting. The protein also binds to the gene product: in immature frogs it is stored as a complex with 5S RNA. From the observation that TFIIIA can bind to either double-helical DNA or RNA, and from their own measurements, Rhodes and Klug have proposed that the DNA-binding site for TFIIIA has an RNA-like structure. Here we present the crystal structure analysis of a part of the DNA-binding site (nucleotides 81-89 of the gene) which forms a particularly strong interaction with the protein, and show that it has a conformation similar to the A' form of double-helical RNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 3748146 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3748146}}
==About this Structure==
==About this Structure==
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[[Category: A-dna]]
[[Category: A-dna]]
[[Category: Double helix]]
[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:02:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:19:40 2008''

Revision as of 20:19, 30 June 2008

Image:1dn6.png

Template:STRUCTURE 1dn6

THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA

Template:ABSTRACT PUBMED 3748146

About this Structure

Full crystallographic information is available from OCA.

Reference

The crystal structure of d(GGATGGGAG): an essential part of the binding site for transcription factor IIIA., McCall M, Brown T, Hunter WN, Kennard O, Nature. 1986 Aug 14-20;322(6080):661-4. PMID:3748146

Page seeded by OCA on Mon Jun 30 23:19:40 2008

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