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1dol

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[[Image:1dol.gif|left|200px]]
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{{STRUCTURE_1dol| PDB=1dol | SCENE= }}
{{STRUCTURE_1dol| PDB=1dol | SCENE= }}
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'''MONOCYTE CHEMOATTRACTANT PROTEIN 1, I-FORM'''
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===MONOCYTE CHEMOATTRACTANT PROTEIN 1, I-FORM===
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==Overview==
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The X-ray crystal structure of recombinant human monocyte chemoattractant protein (MCP-1) has been solved in two crystal forms. One crystal form (P), refined to 1.85 A resolution, contains a dimer in the asymmetric unit, while the other (I) contains a monomer and was refined at 2.4 A. Although both crystal forms grow together in the same droplet, the respective quaternary structures of the protein differ dramatically. In addition, both X-ray structures differ to a similar extent from the solution structure of MCP-1. Such extent of variability of quaternary structures is unprecedented. In the crystal structures, the well-ordered N termini of MCP-1 form 3(10)-helices. Comparison of the three MCP-1 structures revealed a direct correlation between the main-chain conformation of the first two cysteine residues and the quaternary arrangements. These data can be used to explain the structural basis for the assignment of residues responsible for biological activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 8989326 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8989326}}
==About this Structure==
==About this Structure==
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[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:05:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:23:05 2008''

Revision as of 20:23, 30 June 2008

Image:1dol.png

Template:STRUCTURE 1dol

MONOCYTE CHEMOATTRACTANT PROTEIN 1, I-FORM

Template:ABSTRACT PUBMED 8989326

About this Structure

1DOL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions., Lubkowski J, Bujacz G, Boque L, Domaille PJ, Handel TM, Wlodawer A, Nat Struct Biol. 1997 Jan;4(1):64-9. PMID:8989326

Page seeded by OCA on Mon Jun 30 23:23:05 2008

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