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1du1

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[[Image:1du1.gif|left|200px]]
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{{STRUCTURE_1du1| PDB=1du1 | SCENE= }}
{{STRUCTURE_1du1| PDB=1du1 | SCENE= }}
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'''PEPTIDE FRAGMENT THR671-LEU690 OF THE RABBIT SKELETAL DIHYDROPYRIDINE RECEPTOR'''
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===PEPTIDE FRAGMENT THR671-LEU690 OF THE RABBIT SKELETAL DIHYDROPYRIDINE RECEPTOR===
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==Overview==
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The solution structures of three related peptides (A1, A2, and A9) corresponding to the Thr(671)-Leu(690) region of the skeletal muscle dihydropyridine receptor II-III loop have been investigated using nuclear magnetic resonance spectroscopy. Peptide A1, the native sequence, is less effective in activating ryanodine receptor calcium release channels than A2 (Ser(687) to Ala substitution). Peptide A9, Arg(681)-Ser(687), does not activate ryanodine receptors. A1 and A2 are helical from their N terminus to Lys(685) but are generally unstructured from Lys(685) to the C terminus. The basic residues Arg(681)-Lys(685), essential for A1 activation of ryanodine receptors, are located at the C-terminal end of the alpha-helix. Peptide A9 was found to be unstructured. Differences between A1 and A2 were observed in the C-terminal end of the helix (residues 681-685), which was less ordered in A1, and in the C-terminal region of the peptide, which exhibited greater flexibility in A1. Predicted low energy models suggest that an electrostatic interaction between the hydroxyl oxygen of Ser(687) and the guanidino moiety of Arg(683) is lost with the Ser(687)Ala substitution. The results show that the more structured peptides are more effective in activating ryanodine receptors.
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The line below this paragraph, {{ABSTRACT_PUBMED_10766780}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10766780 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10766780}}
==About this Structure==
==About this Structure==
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1DU1 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DU1 OCA].
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1DU1 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DU1 OCA].
==Reference==
==Reference==
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[[Category: Nmr structure]]
[[Category: Nmr structure]]
[[Category: Ryanodine receptor]]
[[Category: Ryanodine receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:16:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:36:59 2008''

Revision as of 20:37, 30 June 2008

Image:1du1.png

Template:STRUCTURE 1du1

PEPTIDE FRAGMENT THR671-LEU690 OF THE RABBIT SKELETAL DIHYDROPYRIDINE RECEPTOR

Template:ABSTRACT PUBMED 10766780

About this Structure

1DU1 is a Single protein structure. Full experimental information is available from OCA.

Reference

A structural requirement for activation of skeletal ryanodine receptors by peptides of the dihydropyridine receptor II-III loop., Casarotto MG, Gibson F, Pace SM, Curtis SM, Mulcair M, Dulhunty AF, J Biol Chem. 2000 Apr 21;275(16):11631-7. PMID:10766780

Page seeded by OCA on Mon Jun 30 23:36:59 2008

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