1dyk

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[[Image:1dyk.gif|left|200px]]
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{{STRUCTURE_1dyk| PDB=1dyk | SCENE= }}
{{STRUCTURE_1dyk| PDB=1dyk | SCENE= }}
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'''LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR'''
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===LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR===
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==Overview==
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The laminins are large heterotrimeric glycoproteins with fundamental roles in basement membrane architecture and function. The C-terminus of the laminin alpha chain contains a tandem of five laminin G-like (LG) domains. We report the 2.0 A crystal structure of the laminin alpha2 LG4-LG5 domain pair, which harbours binding sites for heparin and the cell surface receptor alpha-dystroglycan, and is 41% identical to the laminin alpha1 E3 fragment. LG4 and LG5 are arranged in a V-shaped fashion related by a 110 degrees rotation about an axis passing near the domain termini. An extended N-terminal segment is disulfide bonded to LG5 and stabilizes the domain pair. Two calcium ions, one each in LG4 and LG5, are located 65 A apart at the tips of the domains opposite the polypeptide termini. An extensive basic surface region between the calcium sites is proposed to bind alpha-dystroglycan and heparin. The LG4-LG5 structure was used to construct a model of the laminin LG1-LG5 tandem and interpret missense mutations underlying protein S deficiency.
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The line below this paragraph, {{ABSTRACT_PUBMED_10747011}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10747011 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10747011}}
==About this Structure==
==About this Structure==
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[[Category: Tisi, D.]]
[[Category: Tisi, D.]]
[[Category: Laminin]]
[[Category: Laminin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:26:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:48:52 2008''

Revision as of 20:48, 30 June 2008

Image:1dyk.png

Template:STRUCTURE 1dyk

LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR

Template:ABSTRACT PUBMED 10747011

About this Structure

1DYK is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the C-terminal laminin G-like domain pair of the laminin alpha2 chain harbouring binding sites for alpha-dystroglycan and heparin., Tisi D, Talts JF, Timpl R, Hohenester E, EMBO J. 2000 Apr 3;19(7):1432-40. PMID:10747011

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