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1e0e

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{{STRUCTURE_1e0e| PDB=1e0e | SCENE= }}
{{STRUCTURE_1e0e| PDB=1e0e | SCENE= }}
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'''N-TERMINAL ZINC-BINDING HHCC DOMAIN OF HIV-2 INTEGRASE'''
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===N-TERMINAL ZINC-BINDING HHCC DOMAIN OF HIV-2 INTEGRASE===
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==Overview==
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The solution structure of the dimeric N-terminal domain of HIV-2 integrase (residues 1-55, named IN(1-55)) has been determined using NMR spectroscopy. The structure of the monomer, which was already reported previously [Eijkelenboom et al. (1997) Curr. Biol., 7, 739-746], consists of four alpha-helices and is well defined. Helices alpha1, alpha2 and alpha3 form a three-helix bundle that is stabilized by zinc binding to His12, His16, Cys40 and Cys43. The dimer interface is formed by the N-terminal tail and the first half of helix alpha3. The orientation of the two monomeric units with respect to each other shows considerable variation. 15N relaxation studies have been used to characterize the nature of the intermonomeric disorder. Comparison of the dimer interface with that of the well-defined dimer interface of HIV-1 IN(1-55) shows that the latter is stabilized by additional hydrophobic interactions and a potential salt bridge. Similar interactions cannot be formed in HIV-2 IN(1-55) [Cai et al. (1997) Nat. Struct. Biol., 4, 567-577], where the corresponding residues are positively charged and neutral ones.
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The line below this paragraph, {{ABSTRACT_PUBMED_11101216}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11101216 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11101216}}
==About this Structure==
==About this Structure==
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1E0E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1aub 1aub]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0E OCA].
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1E0E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1aub 1aub]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E0E OCA].
==Reference==
==Reference==
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[[Category: Polyprotein]]
[[Category: Polyprotein]]
[[Category: Zinc-binding protein]]
[[Category: Zinc-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:30:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:55:56 2008''

Revision as of 20:56, 30 June 2008

Image:1e0e.png

Template:STRUCTURE 1e0e

N-TERMINAL ZINC-BINDING HHCC DOMAIN OF HIV-2 INTEGRASE

Template:ABSTRACT PUBMED 11101216

About this Structure

1E0E is a Single protein structure of sequence from Viruses. This structure supersedes the now removed PDB entry 1aub. Full experimental information is available from OCA.

Reference

Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase., Eijkelenboom AP, van den Ent FM, Wechselberger R, Plasterk RH, Kaptein R, Boelens R, J Biomol NMR. 2000 Oct;18(2):119-28. PMID:11101216

Page seeded by OCA on Mon Jun 30 23:55:56 2008

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