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1e9z

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[[Image:1e9z.gif|left|200px]]
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{{Seed}}
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[[Image:1e9z.png|left|200px]]
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{{STRUCTURE_1e9z| PDB=1e9z | SCENE= }}
{{STRUCTURE_1e9z| PDB=1e9z | SCENE= }}
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'''CRYSTAL STRUCTURE OF HELICOBACTER PYLORI UREASE'''
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===CRYSTAL STRUCTURE OF HELICOBACTER PYLORI UREASE===
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==Overview==
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Helicobacter pylori, an etiologic agent in a variety of gastroduodenal diseases, produces a large amount of urease, which is believed to neutralize gastric acid by producing ammonia for the survival of the bacteria. Up to 30% of the enzyme associates with the surface of intact cells upon lysis of neighboring bacteria. The role of the enzyme at the extracellular location has been a subject of controversy because the purified enzyme is irreversibly inactivated below pH 5. We have determined the crystal structure of H. pylori urease, which has a 1.1 MDa spherical assembly of 12 catalytic units with an outer diameter of approximately 160 A. Under physiologically relevant conditions, the activity of the enzyme remains unaffected down to pH 3. Activity assays under different conditions indicated that the cluster of the 12 active sites on the supramolecular assembly may be critical for the survival of the enzyme at low pH. The structure provides a novel example of a molecular assembly adapted for acid resistance that, together with the low Km value of the enzyme, is likely to enable the organism to inhabit the hostile niche.
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The line below this paragraph, {{ABSTRACT_PUBMED_11373617}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11373617 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11373617}}
==About this Structure==
==About this Structure==
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[[Category: Helicobacter]]
[[Category: Helicobacter]]
[[Category: Urease]]
[[Category: Urease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:51:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:23:14 2008''

Revision as of 21:23, 30 June 2008

Image:1e9z.png

Template:STRUCTURE 1e9z

CRYSTAL STRUCTURE OF HELICOBACTER PYLORI UREASE

Template:ABSTRACT PUBMED 11373617

About this Structure

1E9Z is a Protein complex structure of sequences from Helicobacter pylori. Full crystallographic information is available from OCA.

Reference

Supramolecular assembly and acid resistance of Helicobacter pylori urease., Ha NC, Oh ST, Sung JY, Cha KA, Lee MH, Oh BH, Nat Struct Biol. 2001 Jun;8(6):505-9. PMID:11373617

Page seeded by OCA on Tue Jul 1 00:23:14 2008

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