1egg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1egg.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1egg.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1egg| PDB=1egg | SCENE= }}
{{STRUCTURE_1egg| PDB=1egg | SCENE= }}
-
'''STRUCTURE OF A C-TYPE CARBOHYDRATE-RECOGNITION DOMAIN (CRD-4) FROM THE MACROPHAGE MANNOSE RECEPTOR'''
+
===STRUCTURE OF A C-TYPE CARBOHYDRATE-RECOGNITION DOMAIN (CRD-4) FROM THE MACROPHAGE MANNOSE RECEPTOR===
-
==Overview==
+
<!--
-
The mannose receptor of macrophages and liver endothelium mediates clearance of pathogenic organisms and potentially harmful glycoconjugates. The extracellular portion of the receptor includes eight C-type carbohydrate recognition domains (CRDs), of which one, CRD-4, shows detectable binding to monosaccharide ligands. We have determined the crystal structure of CRD-4. Although the basic C-type lectin fold is preserved, a loop extends away from the core of the domain to form a domain-swapped dimer in the crystal. Of the two Ca(2+) sites, only the principal site known to mediate carbohydrate binding in other C-type lectins is occupied. This site is altered in a way that makes sugar binding impossible in the mode observed in other C-type lectins. The structure is likely to represent an endosomal form of the domain formed when Ca(2+) is lost from the auxiliary calcium site. The structure suggests a mechanism for endosomal ligand release in which the auxiliary calcium site serves as a pH sensor. Acid pH-induced removal of this Ca(2+) results in conformational rearrangements of the receptor, rendering it unable to bind carbohydrate ligands.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10779515}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10779515 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10779515}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: C-type lectin]]
[[Category: C-type lectin]]
[[Category: Mannose receptor]]
[[Category: Mannose receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:04:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:39:37 2008''

Revision as of 21:39, 30 June 2008

Image:1egg.png

Template:STRUCTURE 1egg

STRUCTURE OF A C-TYPE CARBOHYDRATE-RECOGNITION DOMAIN (CRD-4) FROM THE MACROPHAGE MANNOSE RECEPTOR

Template:ABSTRACT PUBMED 10779515

About this Structure

1EGG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor., Feinberg H, Park-Snyder S, Kolatkar AR, Heise CT, Taylor ME, Weis WI, J Biol Chem. 2000 Jul 14;275(28):21539-48. PMID:10779515

Page seeded by OCA on Tue Jul 1 00:39:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1egg"
Personal tools