1egp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1egp.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1egp.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1egp| PDB=1egp | SCENE= }}
{{STRUCTURE_1egp| PDB=1egp | SCENE= }}
-
'''PROTEINASE INHIBITOR EGLIN C WITH HYDROLYSED REACTIVE CENTER'''
+
===PROTEINASE INHIBITOR EGLIN C WITH HYDROLYSED REACTIVE CENTER===
-
==Overview==
+
<!--
-
The inhibition of serine proteinases by both synthetic and natural inhibitors has been widely studied. Eglin c is a small thermostable protein isolated from the leech, Hirudo medicinalis. Eglin c is a potent serine proteinase inhibitor. The three-dimensional structure of native eglin and of its complexes with a number of proteinases are known. We here describe the crystal structure of hydrolysed eglin not bound to a proteinase. The body of the eglin has a conformation remarkably similar to that in the known complexes with proteinases. However, the peptide chain has been cut at the 'scissile' bond between residues 45 and 46, presumed to result from the presence of subtilisin DY in the crystallisation sample. The residues usually making up the inhibiting loop of eglin take up a quite different conformation in the nicked inhibitor leading to stabilising contacts between neighbouring molecules in the crystal. The structure was solved by molecular replacement techniques and refined to a final R-factor of 14.5%.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8425603}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8425603 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8425603}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Wilson, K S.]]
[[Category: Wilson, K S.]]
[[Category: Proteinase inhibitor]]
[[Category: Proteinase inhibitor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:04:51 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:40:20 2008''

Revision as of 21:40, 30 June 2008

Image:1egp.png

Template:STRUCTURE 1egp

PROTEINASE INHIBITOR EGLIN C WITH HYDROLYSED REACTIVE CENTER

Template:ABSTRACT PUBMED 8425603

About this Structure

1EGP is a Protein complex structure of sequences from Hirudo medicinalis. Full crystallographic information is available from OCA.

Reference

Structure of the proteinase inhibitor eglin c with hydrolysed reactive centre at 2.0 A resolution., Betzel C, Dauter Z, Genov N, Lamzin V, Navaza J, Schnebli HP, Visanji M, Wilson KS, FEBS Lett. 1993 Feb 15;317(3):185-8. PMID:8425603

Page seeded by OCA on Tue Jul 1 00:40:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1egp"
Personal tools