1em2

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{{STRUCTURE_1em2| PDB=1em2 | SCENE= }}
{{STRUCTURE_1em2| PDB=1em2 | SCENE= }}
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'''STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64'''
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===STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64===
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==Overview==
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The steroidogenic acute regulatory protein (StAR) regulates acute steroidogenesis in the adrenal cortex and gonads by promoting the translocation of cholesterol to the mitochondrial inner membrane where the first step in steriod biosynthesis is catalyzed. StAR-related lipid transfer (START) domains occur in proteins involved in lipid transport and metabolism, signal transduction, and transcriptional regulation. The 2.2 A resolution crystal structure of the START domain of human MLN64 reported here reveals an alpha/beta fold built around a U-shaped incomplete beta-barrel. The interior of the protein encompasses a 26 x 12 x 11 A hydrophobic tunnel that is large enough to bind a single cholesterol molecule. The StAR and MLN64 START domains bind 1 mole of 14C cholesterol per mole of protein in vitro. Based on the START domain structure and cholesterol binding stoichiometry, it is proposed that StAR acts by shuttling cholesterol molecules one at a time through the intermembrane space of the mitochondrion.
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(as it appears on PubMed at http://www.pubmed.gov), where 10802740 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10802740}}
==About this Structure==
==About this Structure==
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[[Category: Tsujishita, Y.]]
[[Category: Tsujishita, Y.]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
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Revision as of 21:58, 30 June 2008

Image:1em2.png

Template:STRUCTURE 1em2

STAR-RELATED LIPID TRANSPORT DOMAIN OF MLN64

Template:ABSTRACT PUBMED 10802740

About this Structure

1EM2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and lipid transport mechanism of a StAR-related domain., Tsujishita Y, Hurley JH, Nat Struct Biol. 2000 May;7(5):408-14. PMID:10802740

Page seeded by OCA on Tue Jul 1 00:58:06 2008

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