1enh

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{{STRUCTURE_1enh| PDB=1enh | SCENE= }}
{{STRUCTURE_1enh| PDB=1enh | SCENE= }}
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'''STRUCTURAL STUDIES OF THE ENGRAILED HOMEODOMAIN'''
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===STRUCTURAL STUDIES OF THE ENGRAILED HOMEODOMAIN===
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==Overview==
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The structure of the Drosophila engrailed homeodomain has been solved by molecular replacement and refined to an R-factor of 19.7% at a resolution of 2.1 A. This structure offers a high-resolution view of an important family of DNA-binding proteins and allows comparison to the structure of the same protein bound to DNA. The most significant difference between the current structure and that of the 2.8-A engrailed-DNA complex is the close packing of an extended strand against the rest of the protein in the unbound protein. Structural features of the protein not previously noted include a "herringbone" packing of 4 aromatic residues in the core of the protein and an extensive network of salt bridges that covers much of the helix 1-helix 2 surface. Other features that may play a role in stabilizing the native state include the interaction of buried carbonyl oxygen atoms with the edge of Phe 49 and a bias toward statistically preferred side-chain dihedral angles. There is substantial disorder at both ends of the 61 amino acid protein. A 51-amino acid variant of engrailed (residues 6-56) was synthesized and shown by CD and thermal denaturation studies to be structurally and thermodynamically similar to the full-length domain.
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The line below this paragraph, {{ABSTRACT_PUBMED_7849596}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7849596 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7849596}}
==About this Structure==
==About this Structure==
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[[Category: Pabo, C O.]]
[[Category: Pabo, C O.]]
[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:18:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:04:41 2008''

Revision as of 22:04, 30 June 2008

Image:1enh.png

Template:STRUCTURE 1enh

STRUCTURAL STUDIES OF THE ENGRAILED HOMEODOMAIN

Template:ABSTRACT PUBMED 7849596

About this Structure

1ENH is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural studies of the engrailed homeodomain., Clarke ND, Kissinger CR, Desjarlais J, Gilliland GL, Pabo CO, Protein Sci. 1994 Oct;3(10):1779-87. PMID:7849596

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