1ep4

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{{STRUCTURE_1ep4| PDB=1ep4 | SCENE= }}
{{STRUCTURE_1ep4| PDB=1ep4 | SCENE= }}
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'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153'''
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===CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153===
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==Overview==
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S-1153 (AG1549) is perhaps the most promising non-nucleoside inhibitor of HIV-1 reverse transcriptase currently under development as a potential anti-AIDS drug, because it has a favorable profile of resilience to many drug resistance mutations. We have determined the crystal structure of S-1153 in a complex with HIV-1 reverse transcriptase. The complex possesses some novel features, including an extensive network of hydrogen bonds involving the main chain of residues 101, 103, and 236 of the p66 reverse transcriptase subunit. Such interactions are unlikely to be disrupted by side chain mutations. The reverse transcriptase/S-1153 complex suggests different ways in which resilience to mutations in the non-nucleoside inhibitors of reverse transcriptase binding site can be achieved.
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{{ABSTRACT_PUBMED_10799511}}
==About this Structure==
==About this Structure==
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[[Category: Non-nucleoside inhibitor]]
[[Category: Non-nucleoside inhibitor]]
[[Category: S-1153]]
[[Category: S-1153]]
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Revision as of 22:26, 30 June 2008

Image:1ep4.png

Template:STRUCTURE 1ep4

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153

Template:ABSTRACT PUBMED 10799511

About this Structure

1EP4 is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding., Ren J, Nichols C, Bird LE, Fujiwara T, Sugimoto H, Stuart DI, Stammers DK, J Biol Chem. 2000 May 12;275(19):14316-20. PMID:10799511

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