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1epw

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[[Image:1epw.gif|left|200px]]
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[[Image:1epw.png|left|200px]]
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{{STRUCTURE_1epw| PDB=1epw | SCENE= }}
{{STRUCTURE_1epw| PDB=1epw | SCENE= }}
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'''CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B'''
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===CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B===
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==Overview==
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Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its catalytic and binding sites. The position of the belt region in BoNT/B is different from that in BoNT/A; this observation presents interesting possibilities for designing specific inhibitors that could be used to block the activity of this neurotoxin. The structures of BoNT/B and its complex with sialyllactose provide a detailed description of the active site and a model for interactions between the toxin and its cell surface receptor. The latter may provide valuable information for recombinant vaccine development.
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(as it appears on PubMed at http://www.pubmed.gov), where 10932256 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10932256}}
==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:23:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:34:59 2008''

Revision as of 22:35, 30 June 2008

Image:1epw.png

Template:STRUCTURE 1epw

CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B

Template:ABSTRACT PUBMED 10932256

About this Structure

1EPW is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:10932256

Page seeded by OCA on Tue Jul 1 01:34:59 2008

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