1esf

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[[Image:1esf.gif|left|200px]]
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{{Seed}}
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[[Image:1esf.png|left|200px]]
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{{STRUCTURE_1esf| PDB=1esf | SCENE= }}
{{STRUCTURE_1esf| PDB=1esf | SCENE= }}
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'''STAPHYLOCOCCAL ENTEROTOXIN A'''
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===STAPHYLOCOCCAL ENTEROTOXIN A===
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==Overview==
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Staphylococcal enterotoxins are prototype superantigens characterized by their ability to bind to major histocompatibility complex (MHC) class II molecules and subsequently activate a large fraction of T-lymphocytes. The crystal structure of staphylococcal enterotoxin type A (SEA), a 27 kDa monomeric protein, was determined to 1.9 A resolution with an R-factor of 19.9% by multiple isomorphous replacement. SEA is a two domain protein composed of a beta-barrel and a beta-grasp motif demonstrating the same general structure as staphylococcal enterotoxins SEB and TSST-1. Unique for SEA, however, is a Zn2+ coordination site involved in MHC class II binding. Four amino acids including Ser1, His187, His225 and Asp227 were found to be involved in direct coordination of the metal ion. SEA is the first Zn2+ binding enterotoxin that has been structurally determined.
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The line below this paragraph, {{ABSTRACT_PUBMED_7628431}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7628431 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7628431}}
==About this Structure==
==About this Structure==
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[[Category: Enterotoxin]]
[[Category: Enterotoxin]]
[[Category: Staphylococcal enterotoxin type some]]
[[Category: Staphylococcal enterotoxin type some]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:28:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:48:36 2008''

Revision as of 22:48, 30 June 2008

Image:1esf.png

Template:STRUCTURE 1esf

STAPHYLOCOCCAL ENTEROTOXIN A

Template:ABSTRACT PUBMED 7628431

About this Structure

1ESF is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the superantigen staphylococcal enterotoxin type A., Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA, EMBO J. 1995 Jul 17;14(14):3292-301. PMID:7628431

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