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1evo

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{{STRUCTURE_1evo| PDB=1evo | SCENE= }}
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'''NMR OBSERVATION OF A NOVEL C-TETRAD'''
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===NMR OBSERVATION OF A NOVEL C-TETRAD===
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==Overview==
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We report the NMR structure of the DNA sequence d-TGGGCGGT in Na(+) solutions at neutral pH, containing a repeat sequence from SV40 viral genome. The structure is a novel quadruplex incorporating the C-tetrad formed by symmetrical pairing of four Cs via NH(2)&bond;O(2) H-bonds in a plane. The C-tetrad has a wider cavity compared to G-tetrads and stacks well over the adjacent G4-tetrad, but poorly on the G6 tetrad. The quadruplex helix is largely underwound by 8-10 degrees compared to B-DNA except at the C5-G6 step. To our knowledge this is the first report of C-tetrad formation in DNA structures, and would be of significance from the point of view of both structural diversity and specific recognition.
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{{ABSTRACT_PUBMED_10772934}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVO OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVO OCA].
==Reference==
==Reference==
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[[Category: Nmr structure]]
[[Category: Nmr structure]]
[[Category: Sv40]]
[[Category: Sv40]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:34:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:05:46 2008''

Revision as of 23:05, 30 June 2008

Image:1evo.png

Template:STRUCTURE 1evo

NMR OBSERVATION OF A NOVEL C-TETRAD

Template:ABSTRACT PUBMED 10772934

About this Structure

Full experimental information is available from OCA.

Reference

NMR observation of a novel C-tetrad in the structure of the SV40 repeat sequence GGGCGG., Patel PK, Bhavesh NS, Hosur RV, Biochem Biophys Res Commun. 2000 Apr 21;270(3):967-71. PMID:10772934

Page seeded by OCA on Tue Jul 1 02:05:46 2008

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