1exf

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{{STRUCTURE_1exf| PDB=1exf | SCENE= }}
{{STRUCTURE_1exf| PDB=1exf | SCENE= }}
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'''EXFOLIATIVE TOXIN A'''
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===EXFOLIATIVE TOXIN A===
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==Overview==
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Exfoliative toxin A (ETA) causes staphylococcal scalded skin syndrome which is characterized by a specific intraepidermal separation of layers of the skin. The mechanism by which ETA causes skin separation is unknown although protease or superantigen activity has been implicated. The X-ray crystal structure of ETA has been solved in two crystal forms to 2.1 and 2.3 A resolution and R-factors of 17% and 19%, respectively. The structures indicate that ETA belongs to the chymotrypsin-like family of serine proteases and cleaves substrates after acidic residues. The conformation of a loop adjacent to the catalytic site is suggested to be key in regulating the proteolytic activity of ETA through controlling whether the main chain carbonyl group of Pro192 occupies the oxyanion hole. A unique amino-terminal domain containing a 15-residue amphipathic alpha helix may also be involved in protease activation through binding a specific receptor. Substitution of the active site serine residue with cysteine abolishes the ability of ETA to produce the characteristic separation of epidermal layers but not its ability to induce T cell proliferation.
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(as it appears on PubMed at http://www.pubmed.gov), where 9048539 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9048539}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Superantigen]]
[[Category: Superantigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:10:05 2008''

Revision as of 23:10, 30 June 2008

Image:1exf.png

Template:STRUCTURE 1exf

EXFOLIATIVE TOXIN A

Template:ABSTRACT PUBMED 9048539

About this Structure

1EXF is a Single protein structure of sequence from Staphylococcus aureus and Unidentified. Full crystallographic information is available from OCA.

Reference

The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease., Vath GM, Earhart CA, Rago JV, Kim MH, Bohach GA, Schlievert PM, Ohlendorf DH, Biochemistry. 1997 Feb 18;36(7):1559-66. PMID:9048539

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