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1exz

From Proteopedia

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[[Image:1exz.gif|left|200px]]
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{{STRUCTURE_1exz| PDB=1exz | SCENE= }}
{{STRUCTURE_1exz| PDB=1exz | SCENE= }}
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'''STRUCTURE OF STEM CELL FACTOR'''
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===STRUCTURE OF STEM CELL FACTOR===
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==Overview==
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Stem cell factor (SCF) plays important roles in hematopoiesis and the survival, proliferation, and differentiation of mast cells, melanocytes, and germ cells. SCF mediates its biological effects by binding to and activating a receptor tyrosine kinase designated c-kit or SCF receptor. In this report we describe the 2.3-A crystal structure of the functional core of recombinant human SCF. SCF is a noncovalent homodimer composed of two slightly wedged protomers. Each SCF protomer exhibits an antiparallel four-helix bundle fold. Dimerization is mediated by extensive polar and nonpolar interactions between the two protomers with a large buried surface area. Finally, we have identified a hydrophobic crevice and a charged region at the tail of each protomer that functions as a potential receptor-binding site. On the basis of these observations, a model for SCF small middle dotc-kit complex formation and dimerization is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 10884405 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10884405}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, Z.]]
[[Category: Zhang, Z.]]
[[Category: Scf]]
[[Category: Scf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:39:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:11:30 2008''

Revision as of 23:11, 30 June 2008

Image:1exz.png

Template:STRUCTURE 1exz

STRUCTURE OF STEM CELL FACTOR

Template:ABSTRACT PUBMED 10884405

About this Structure

1EXZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation., Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong XP, Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7732-7. PMID:10884405

Page seeded by OCA on Tue Jul 1 02:11:30 2008

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