1f0k

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[[Image:1f0k.gif|left|200px]]
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{{Seed}}
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[[Image:1f0k.png|left|200px]]
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{{STRUCTURE_1f0k| PDB=1f0k | SCENE= }}
{{STRUCTURE_1f0k| PDB=1f0k | SCENE= }}
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'''THE 1.9 ANGSTROM CRYSTAL STRUCTURE OF E. COLI MURG'''
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===THE 1.9 ANGSTROM CRYSTAL STRUCTURE OF E. COLI MURG===
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==Overview==
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The 1.9 A X-ray structure of a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis is reported. This enzyme, MurG, contains two alpha/beta open sheet domains separated by a deep cleft. Structural analysis suggests that the C-terminal domain contains the UDP-GlcNAc binding site while the N-terminal domain contains the acceptor binding site and likely membrane association site. Combined with sequence data from other MurG homologs, this structure provides insight into the residues that are important in substrate binding and catalysis. We have also noted that a conserved region found in many UDP-sugar transferases maps to a beta/alpha/beta/alpha supersecondary structural motif in the donor binding region of MurG, an observation that may be helpful in glycosyltransferase structure prediction. The identification of a conserved structural motif involved in donor binding in different UDP-sugar transferases also suggests that it may be possible to identify--and perhaps alter--the residues that help determine donor specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_10892798}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10892798 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10892798}}
==About this Structure==
==About this Structure==
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[[Category: Walker, S.]]
[[Category: Walker, S.]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:44:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:18:05 2008''

Revision as of 23:18, 30 June 2008

Image:1f0k.png

Template:STRUCTURE 1f0k

THE 1.9 ANGSTROM CRYSTAL STRUCTURE OF E. COLI MURG

Template:ABSTRACT PUBMED 10892798

About this Structure

1F0K is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The 1.9 A crystal structure of Escherichia coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis., Ha S, Walker D, Shi Y, Walker S, Protein Sci. 2000 Jun;9(6):1045-52. PMID:10892798

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