1f1c

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{{STRUCTURE_1f1c| PDB=1f1c | SCENE= }}
{{STRUCTURE_1f1c| PDB=1f1c | SCENE= }}
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'''CRYSTAL STRUCTURE OF CYTOCHROME C549'''
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===CRYSTAL STRUCTURE OF CYTOCHROME C549===
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==Overview==
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Cytochrome c(6) and cytochrome c-549 are small (89 and 130 amino acids, respectively) monoheme cytochromes that function in photosynthesis. They appear to have descended relatively recently from the same ancestral gene but have diverged to carry out very different functional roles, underscored by the large difference between their midpoint potentials of nearly 600 mV. We have determined the X-ray crystal structures of both proteins isolated from the cyanobacterium Arthrospira maxima. The two structures are remarkably similar, superimposing on backbone atoms with an rmsd of 0.7 A. Comparison of the two structures suggests that differences in solvent exposure of the heme and the electrostatic environment of the heme propionates, as well as in heme iron ligation, are the main determinants of midpoint potential in the two proteins. In addition, the crystal packing of both A. maxima cytochrome c-549 and cytochrome c(6) suggests that the proteins oligomerize. Finally, the cytochrome c-549 dimer we observe can be readily fit into the recently described model of cyanobacterial photosystem II.
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(as it appears on PubMed at http://www.pubmed.gov), where 11478889 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11478889}}
==About this Structure==
==About this Structure==
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[[Category: Yeates, T O.]]
[[Category: Yeates, T O.]]
[[Category: Dimeric cytochrome]]
[[Category: Dimeric cytochrome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:46:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:20:12 2008''

Revision as of 23:20, 30 June 2008

Image:1f1c.png

Template:STRUCTURE 1f1c

CRYSTAL STRUCTURE OF CYTOCHROME C549

Template:ABSTRACT PUBMED 11478889

About this Structure

1F1C is a Single protein structure of sequence from Arthrospira maxima. Full crystallographic information is available from OCA.

Reference

Structures of cytochrome c-549 and cytochrome c6 from the cyanobacterium Arthrospira maxima., Sawaya MR, Krogmann DW, Serag A, Ho KK, Yeates TO, Kerfeld CA, Biochemistry. 2001 Aug 7;40(31):9215-25. PMID:11478889

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