This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1f3d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1f3d.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1f3d.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1f3d| PDB=1f3d | SCENE= }}
{{STRUCTURE_1f3d| PDB=1f3d | SCENE= }}
-
'''CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.'''
+
===CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.===
-
==Overview==
+
<!--
-
The crystal structure of the complex of a catalytic antibody with its cationic hapten at 1.9-A resolution demonstrates that the hapten amidinium group is stabilized through an ionic pair interaction with the carboxylate of a combining-site residue. The location of this carboxylate allows it to act as a general base in an allylic rearrangement. When compared with structures of other antibody complexes in which the positive moiety of the hapten is stabilized mostly by cation-pi interactions, this structure shows that the amidinium moiety is a useful candidate to elicit a carboxylate in an antibody combining site at a predetermined location with respect to the hapten. More generally, this structure highlights the advantage of a bidentate hapten for the programmed positioning of a chemically reactive residue in an antibody through charge complementarity to the hapten.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10963661}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10963661 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10963661}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Catalytic antibody]]
[[Category: Catalytic antibody]]
[[Category: Haptenic charge]]
[[Category: Haptenic charge]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:50:42 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:36:19 2008''

Revision as of 23:36, 30 June 2008

Image:1f3d.png

Template:STRUCTURE 1f3d

CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.

Template:ABSTRACT PUBMED 10963661

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural evidence for a programmed general base in the active site of a catalytic antibody., Golinelli-Pimpaneau B, Goncalves O, Dintinger T, Blanchard D, Knossow M, Tellier C, Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9892-5. PMID:10963661

Page seeded by OCA on Tue Jul 1 02:36:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f3d"
Personal tools