1f3m

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[[Image:1f3m.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1f3m| PDB=1f3m | SCENE= }}
{{STRUCTURE_1f3m| PDB=1f3m | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1'''
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===CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1===
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==Overview==
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The p21-activated kinases (PAKs), stimulated by binding with GTP-liganded forms of Cdc42 or Rac, modulate cytoskeletal actin assembly and activate MAP-kinase pathways. The 2.3 A resolution crystal structure of a complex between the N-terminal autoregulatory fragment and the C-terminal kinase domain of PAK1 shows that GTPase binding will trigger a series of conformational changes, beginning with disruption of a PAK1 dimer and ending with rearrangement of the kinase active site into a catalytically competent state. An inhibitory switch (IS) domain, which overlaps the GTPase binding region of PAK1, positions a polypeptide segment across the kinase cleft. GTPase binding will refold part of the IS domain and unfold the rest. A related switch has been seen in the Wiskott-Aldrich syndrome protein (WASP).
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(as it appears on PubMed at http://www.pubmed.gov), where 10975528 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10975528}}
==About this Structure==
==About this Structure==
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[[Category: Homodimer]]
[[Category: Homodimer]]
[[Category: Kinase domain]]
[[Category: Kinase domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:51:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:37:19 2008''

Revision as of 23:37, 30 June 2008

Image:1f3m.png

Template:STRUCTURE 1f3m

CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1

Template:ABSTRACT PUBMED 10975528

About this Structure

1F3M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch., Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC, Cell. 2000 Aug 4;102(3):387-97. PMID:10975528

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