1f3u

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[[Image:1f3u.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1f3u| PDB=1f3u | SCENE= }}
{{STRUCTURE_1f3u| PDB=1f3u | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF'''
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===CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF===
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==Overview==
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General transcription factor IIF (TFIIF) is required for transcription by RNA polymerase II; it consists minimally of a heterodimer of RNA polymerase-associated proteins RAP30 and RAP74. According to solution and mutagenesis studies, the multiple domains of RAP30 and RAP74 bind PolII, TFIIB, TAF250 and DNA in interactions that are essential for transcription initiation and elongation. The X-ray structure of the RAP30/RAP74 interaction domains at 1.7 A resolution reveals a novel "triple barrel" dimerization fold and suggests with mutant data that interactions with the transcription apparatus are mediated not only by this tripartite beta-barrel, but also via flexible loops and alpha and beta-structures extending from it.
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(as it appears on PubMed at http://www.pubmed.gov), where 11183778 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11183778}}
==About this Structure==
==About this Structure==
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[[Category: Novel dimerization fold]]
[[Category: Novel dimerization fold]]
[[Category: Rna polymerase ii]]
[[Category: Rna polymerase ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:51:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:38:08 2008''

Revision as of 23:38, 30 June 2008

Image:1f3u.png

Template:STRUCTURE 1f3u

CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF

Template:ABSTRACT PUBMED 11183778

About this Structure

1F3U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution., Gaiser F, Tan S, Richmond TJ, J Mol Biol. 2000 Oct 6;302(5):1119-27. PMID:11183778

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