1fai

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[[Image:1fai.gif|left|200px]]
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{{STRUCTURE_1fai| PDB=1fai | SCENE= }}
{{STRUCTURE_1fai| PDB=1fai | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI-ARSONATE ANTIBODY'''
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===THREE-DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI-ARSONATE ANTIBODY===
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==Overview==
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The three-dimensional structure of FabR19.9 from a well-characterized anti-p-azobenzenearsonate monoclonal antibody has been determined by x-ray diffraction techniques in two crystalline forms (I and II) to a resolution of 2.8 and 2.7 A, respectively. Essentially the same tertiary and quaternary structure of the Fab is observed in the two forms. The major difference resides in the intermolecular contacts, which are interpreted to favor an irreversible transition from the metastable form I to the more stable form II. The third complementarity-determining region of the heavy chain (H3) folds back over the combining site and requires rearrangement for hapten binding. This dynamic requirement on H3 is consistent with its mobility in the structure and can explain hapten binding to an otherwise inaccessible antibody combining site.
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The line below this paragraph, {{ABSTRACT_PUBMED_1409652}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1409652 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1409652}}
==About this Structure==
==About this Structure==
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[[Category: Poljak, R J.]]
[[Category: Poljak, R J.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:06:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:57:29 2008''

Revision as of 23:57, 30 June 2008

Image:1fai.png

Template:STRUCTURE 1fai

THREE-DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI-ARSONATE ANTIBODY

Template:ABSTRACT PUBMED 1409652

About this Structure

1FAI is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody., Lascombe MB, Alzari PM, Poljak RJ, Nisonoff A, Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9429-33. PMID:1409652

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