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1fan

From Proteopedia

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{{STRUCTURE_1fan| PDB=1fan | SCENE= }}
{{STRUCTURE_1fan| PDB=1fan | SCENE= }}
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'''CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A'''
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===CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A===
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==Overview==
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Crystal structures of four mutants of bovine pancreatic trypsin inhibitor (F22A, Y23A, N43G, and F45A), engineered to alter their stability properties, have been determined. The mutated residues, which are highly conserved among Kunitz-type inhibitors, are located in the rigid core of the molecule. Replacement of the partially buried bulky residues of the wild-type protein with smaller residues resulted in crevices open to the exterior of the molecule. The overall three-dimensional structure of these mutants is very similar to that of the wild-type protein and only small rearrangements are observed among the atoms lining the crevices.
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(as it appears on PubMed at http://www.pubmed.gov), where 8518731 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8518731}}
==About this Structure==
==About this Structure==
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[[Category: Woodward, C.]]
[[Category: Woodward, C.]]
[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:06:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:57:42 2008''

Revision as of 23:57, 30 June 2008

Image:1fan.png

Template:STRUCTURE 1fan

CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A

Template:ABSTRACT PUBMED 8518731

About this Structure

1FAN is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crevice-forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: crystal structures of F22A, Y23A, N43G, and F45A., Danishefsky AT, Housset D, Kim KS, Tao F, Fuchs J, Woodward C, Wlodawer A, Protein Sci. 1993 Apr;2(4):577-87. PMID:8518731

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