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'''THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE'''
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===THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE===
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==Overview==
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The three-dimensional structure of the complex between an HIV-1 cell-entry inhibitor selected from screening a combinatorial library of non-natural building blocks and the central, trimeric, coiled-coil core of HIV-1 gp41 has been determined by X-ray crystallography. The biased combinatorial library was designed to identify ligands binding in nonpolar pockets on the surface of the coiled-coil core of gp41. The crystal structure shows that the non-peptide moiety of the inhibitor binds to the targeted cavity in two different binding modes. This result suggests a strategy for increasing inhibitor potency by use of a second-generation combinatorial library designed to give simultaneous occupancy of both binding sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 11026535 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11026535}}
==About this Structure==
==About this Structure==
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[[Category: Hiv-1]]
[[Category: Hiv-1]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
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Revision as of 23:58, 30 June 2008

Image:1fav.png

Template:STRUCTURE 1fav

THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE

Template:ABSTRACT PUBMED 11026535

About this Structure

1FAV is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core., Zhou G, Ferrer M, Chopra R, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Harrison SC, Wiley DC, Bioorg Med Chem. 2000 Sep;8(9):2219-27. PMID:11026535

Page seeded by OCA on Tue Jul 1 02:58:20 2008

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