1fbp

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{{STRUCTURE_1fbp| PDB=1fbp | SCENE= }}
{{STRUCTURE_1fbp| PDB=1fbp | SCENE= }}
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'''CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH FRUCTOSE 6-PHOSPHATE, AMP, AND MAGNESIUM'''
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===CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH FRUCTOSE 6-PHOSPHATE, AMP, AND MAGNESIUM===
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==Overview==
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The crystal structure of fructose-1,6-bisphosphatase (EC 3.1.3.11) complexed with fructose 6-phosphate, AMP, and Mg2+ has been solved by the molecular replacement method and refined at 2.5-A resolution to a R factor of 0.215, with root-mean-square deviations of 0.013 A and 3.5 degrees for bond lengths and bond angles, respectively. No solvent molecules have been included in the refinement. This structure shows large quaternary and tertiary conformational changes from the structures of the unligated enzyme or its fructose 2,6-bisphosphate complex, but the secondary structures remain essentially the same. Dimer C3-C4 of the enzyme-fructose 6-phosphate-AMP-Mg2+ complex twists about 19 degrees relative to the same dimer of the enzyme-fructose 2,6-bisphosphate complex if their C1-C2 dimers are superimposed on one another. Nevertheless, many interfacial interactions between dimers of C1-C2 and C3-C4 are conserved after quaternary structure changes occur. Residues of the AMP domain (residues 6-200) show large migrations of C alpha atoms relative to barely significant positional changes of the FBP domain (residues 201-335).
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(as it appears on PubMed at http://www.pubmed.gov), where 2164670 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2164670}}
==About this Structure==
==About this Structure==
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[[Category: Lipscomb, W N.]]
[[Category: Lipscomb, W N.]]
[[Category: Zhang, Y.]]
[[Category: Zhang, Y.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:00:30 2008''

Revision as of 00:00, 1 July 2008

Image:1fbp.png

Template:STRUCTURE 1fbp

CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH FRUCTOSE 6-PHOSPHATE, AMP, AND MAGNESIUM

Template:ABSTRACT PUBMED 2164670

About this Structure

1FBP is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 6-phosphate, AMP, and magnesium., Ke HM, Zhang YP, Lipscomb WN, Proc Natl Acad Sci U S A. 1990 Jul;87(14):5243-7. PMID:2164670

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