1fyf

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{{Seed}}
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{{STRUCTURE_1fyf| PDB=1fyf | SCENE= }}
{{STRUCTURE_1fyf| PDB=1fyf | SCENE= }}
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'''CRYSTAL STRUCTURE OF A TRUNCATED FORM OF THREONYL-TRNA SYNTHETASE COMPLEXED WITH A SERYL ADENYLATE ANALOG'''
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===CRYSTAL STRUCTURE OF A TRUNCATED FORM OF THREONYL-TRNA SYNTHETASE COMPLEXED WITH A SERYL ADENYLATE ANALOG===
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==Overview==
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Threonyl-tRNA synthetase, a class II synthetase, uses a unique zinc ion to discriminate against the isosteric valine at the activation step. The crystal structure of the enzyme with an analog of seryl adenylate shows that the noncognate serine cannot be fully discriminated at that step. We show that hydrolysis of the incorrectly formed ser-tRNA(Thr) is performed at a specific site in the N-terminal domain of the enzyme. The present study suggests that both classes of synthetases use effectively the ability of the CCA end of tRNA to switch between a hairpin and a helical conformation for aminoacylation and editing. As a consequence, the editing mechanism of both classes of synthetases can be described as mirror images, as already seen for tRNA binding and amino acid activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_11136973}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11136973 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11136973}}
==About this Structure==
==About this Structure==
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[[Category: Trna-synthetase]]
[[Category: Trna-synthetase]]
[[Category: Zinc ion]]
[[Category: Zinc ion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:54:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:07:39 2008''

Revision as of 01:07, 1 July 2008

Image:1fyf.png

Template:STRUCTURE 1fyf

CRYSTAL STRUCTURE OF A TRUNCATED FORM OF THREONYL-TRNA SYNTHETASE COMPLEXED WITH A SERYL ADENYLATE ANALOG

Template:ABSTRACT PUBMED 11136973

About this Structure

1FYF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Transfer RNA-mediated editing in threonyl-tRNA synthetase. The class II solution to the double discrimination problem., Dock-Bregeon A, Sankaranarayanan R, Romby P, Caillet J, Springer M, Rees B, Francklyn CS, Ehresmann C, Moras D, Cell. 2000 Dec 8;103(6):877-84. PMID:11136973

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