1fzo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fzo.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1fzo.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fzo| PDB=1fzo | SCENE= }}
{{STRUCTURE_1fzo| PDB=1fzo | SCENE= }}
-
'''MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN'''
+
===MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN===
-
==Overview==
+
<!--
-
The K(bm1) and K(bm8) natural mutants of the murine MHC class I molecule H-2K(b) were originally identified by allograft rejection. They also bind viral peptides VSV8 and SEV9 with high affinity, but their peptide complexes have substantially decreased thermostability, and the K(bm1) complexes do not elicit alloreactive T cell responses. Crystal structures of the four mutant complexes at 1.7-1.9 A resolution are similar to the corresponding wild-type K(b) structures, except in the vicinity of the mutated residues, which alter the electrostatic potential, topology, hydrogen bonding, and local water structure of the peptide binding groove. Thus, these natural K(b) mutations define the minimal perturbations in the peptide environment that alter antigen presentation to T cells and abolish alloreactivity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11290333}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11290333 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11290333}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Major histocompatibility complex peptide-mhc]]
[[Category: Major histocompatibility complex peptide-mhc]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:56:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:10:47 2008''

Revision as of 01:10, 1 July 2008

Image:1fzo.png

Template:STRUCTURE 1fzo

MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN

Template:ABSTRACT PUBMED 11290333

About this Structure

1FZO is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity., Rudolph MG, Speir JA, Brunmark A, Mattsson N, Jackson MR, Peterson PA, Teyton L, Wilson IA, Immunity. 2001 Mar;14(3):231-42. PMID:11290333

Page seeded by OCA on Tue Jul 1 04:10:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fzo"
Personal tools