1g0y

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[[Image:1g0y.gif|left|200px]]
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{{Seed}}
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[[Image:1g0y.png|left|200px]]
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{{STRUCTURE_1g0y| PDB=1g0y | SCENE= }}
{{STRUCTURE_1g0y| PDB=1g0y | SCENE= }}
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'''IL-1 RECEPTOR TYPE 1 COMPLEXED WITH ANTAGONIST PEPTIDE AF10847'''
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===IL-1 RECEPTOR TYPE 1 COMPLEXED WITH ANTAGONIST PEPTIDE AF10847===
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==Overview==
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Interleukin (IL-1)alpha and IL-1beta are important mediators of inflammation. The binding of IL-1 to interleukin-1 receptor (IL-1R) type 1 is the initial step in IL-1 signal transduction and therefore is a tempting target for anti-inflammatory therapeutics. To advance our understanding of IL-1R1 binding interactions, we have determined the structure of the extracellular domains of IL-1R1 bound to a 21-amino acid IL-1 antagonist peptide at 3.0-A resolution. The antagonist peptide binds to the domain 1/2 junction of the receptor, which is a conserved binding site for IL-1beta and IL-1 receptor antagonist (IL-1ra). This co-crystal structure also reveals that considerable flexibility is present in IL-1R1 because the carboxyl-terminal domain of the receptor is rotated almost 170 degrees relative to the first two domains of the receptor compared with the previously solved IL-1R1.ligand structures. The structure shows an unexpected binding mode for the peptide and may contribute to the design of smaller IL-1R antagonists.
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The line below this paragraph, {{ABSTRACT_PUBMED_10903327}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10903327 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10903327}}
==About this Structure==
==About this Structure==
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[[Category: Vigers, G P.A.]]
[[Category: Vigers, G P.A.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:59:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:14:24 2008''

Revision as of 01:14, 1 July 2008

Image:1g0y.png

Template:STRUCTURE 1g0y

IL-1 RECEPTOR TYPE 1 COMPLEXED WITH ANTAGONIST PEPTIDE AF10847

Template:ABSTRACT PUBMED 10903327

About this Structure

1G0Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1., Vigers GP, Dripps DJ, Edwards CK 3rd, Brandhuber BJ, J Biol Chem. 2000 Nov 24;275(47):36927-33. PMID:10903327

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