This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1g3x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1g3x.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1g3x.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1g3x| PDB=1g3x | SCENE= }}
{{STRUCTURE_1g3x| PDB=1g3x | SCENE= }}
-
'''INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER'''
+
===INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER===
-
==Overview==
+
<!--
-
We present the crystal structure of an acridine drug derivatized at carbon 9, [N(alpha)-(9-acridinoyl)-tetraarginine], intercalated within the dodecamer [d(CGCGAATTCGCG)](2). The presence of a lateral chain at the central carbon 9 atom differentiates this compound from most acridine drugs hitherto studied, which are usually derivatized at carbon 4. The DNA:drug interaction we observe differs from that observed in previous studies, which primarily involves shorter, mainly hexameric sequences, in two important regards: the acridine intercalates within an AA/TT base step, rather than within a CG/CG base step; and the binding site is located at the center of the sequence, rather than at one end of the duplex. In addition, we observe a novel crystal packing arrangement, with six dodecamer duplexes and seven hydrated magnesium ions in the asymmetric unit of a large (66.5 x 68.4 x 77.4 A(3)) unit cell in space group P2(1)2(1)2(1). The duplexes are organized in layers parallel to the ab plane, with consecutive layers crossing each other at right angles.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12135355}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12135355 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12135355}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Mg+2 ion]]
[[Category: Mg+2 ion]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:06:23 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:22:39 2008''

Revision as of 01:22, 1 July 2008

Image:1g3x.png

Template:STRUCTURE 1g3x

INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER

Template:ABSTRACT PUBMED 12135355

About this Structure

Full crystallographic information is available from OCA.

Reference

Intercalation of an acridine-peptide drug in an AA/TT base step in the crystal structure of [d(CGCGAATTCGCG)](2) with six duplexes and seven Mg(2+) ions in the asymmetric unit., Malinina L, Soler-Lopez M, Aymami J, Subirana JA, Biochemistry. 2002 Jul 30;41(30):9341-8. PMID:12135355

Page seeded by OCA on Tue Jul 1 04:22:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g3x"
Personal tools