1g8h

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{{STRUCTURE_1g8h| PDB=1g8h | SCENE= }}
{{STRUCTURE_1g8h| PDB=1g8h | SCENE= }}
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'''ATP SULFURYLASE FROM S. CEREVISIAE: THE TERNARY PRODUCT COMPLEX WITH APS AND PPI'''
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===ATP SULFURYLASE FROM S. CEREVISIAE: THE TERNARY PRODUCT COMPLEX WITH APS AND PPI===
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==Overview==
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ATP sulfurylases (ATPSs) are ubiquitous enzymes that catalyse the primary step of intracellular sulfate activation: the reaction of inorganic sulfate with ATP to form adenosine-5'-phosphosulfate (APS) and pyrophosphate (PPi). With the crystal structure of ATPS from the yeast Saccharomyces cerevisiae, we have solved the first structure of a member of the ATP sulfurylase family. We have analysed the crystal structure of the native enzyme at 1.95 Angstroms resolution using multiple isomorphous replacement (MIR) and, subsequently, the ternary enzyme product complex with APS and PPi bound to the active site. The enzyme consists of six identical subunits arranged in two stacked rings in a D:3 symmetric assembly. Nucleotide binding causes significant conformational changes, which lead to a rigid body structural displacement of domains III and IV of the ATPS monomer. Despite having similar folds and active site design, examination of the active site of ATPS and comparison with known structures of related nucleotidylyl transferases reveal a novel ATP binding mode that is peculiar to ATP sulfurylases.
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(as it appears on PubMed at http://www.pubmed.gov), where 11157739 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11157739}}
==About this Structure==
==About this Structure==
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[[Category: Product complex with adenosine-5'-phosphosulfate and pyrophosphate]]
[[Category: Product complex with adenosine-5'-phosphosulfate and pyrophosphate]]
[[Category: Rossmann-fold]]
[[Category: Rossmann-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:52:53 2008''

Revision as of 01:52, 1 July 2008

Image:1g8h.png

Template:STRUCTURE 1g8h

ATP SULFURYLASE FROM S. CEREVISIAE: THE TERNARY PRODUCT COMPLEX WITH APS AND PPI

Template:ABSTRACT PUBMED 11157739

About this Structure

1G8H is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation., Ullrich TC, Blaesse M, Huber R, EMBO J. 2001 Feb 1;20(3):316-29. PMID:11157739

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