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1gig

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{{STRUCTURE_1gig| PDB=1gig | SCENE= }}
{{STRUCTURE_1gig| PDB=1gig | SCENE= }}
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'''REFINED THREE-DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A MURINE IGG1, LAMBDA ANTIBODY'''
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===REFINED THREE-DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A MURINE IGG1, LAMBDA ANTIBODY===
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==Overview==
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We report the cDNA sequence determination and the crystal structure of the Fab fragment of a murine IgG1,lambda antibody (HC19), specific for an influenza virus hemagglutinin. The HC19 Fab-fragment structure has been refined; the crystallographic R-factor is 19.5% at 2.3 A resolution. We have compared the conformation of HC19 complementarity determining regions (CDRs) with those of CDR loops of Fab structures available from the Protein Data Bank. These loops were chosen based on the identity of key residues, following the canonical-structure approach; four CDRs have a main-chain conformation very similar to the canonical structure that had been identified. HC19 L1 CDR adopts a conformation clearly distinct from all L1 CDRs that belong to a chain of a different class or origin; this is determined by the nature of a few residues at positions in the sequence different from those of key residues in other light chains. This canonical structure should be representative of most murine lambda-class light chains, as inferred from the very high sequence homologies of these polypeptides.
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(as it appears on PubMed at http://www.pubmed.gov), where 15299376 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299376}}
==About this Structure==
==About this Structure==
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[[Category: Knossow, M.]]
[[Category: Knossow, M.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:36:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:20:46 2008''

Revision as of 02:20, 1 July 2008

Image:1gig.png

Template:STRUCTURE 1gig

REFINED THREE-DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A MURINE IGG1, LAMBDA ANTIBODY

Template:ABSTRACT PUBMED 15299376

About this Structure

1GIG is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

Refined three-dimensional structure of the Fab fragment of a murine IgGl,lambda antibody., Bizebard T, Daniels R, Kahn R, Golinelli-Pimpaneau B, Skehel JJ, Knossow M, Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):768-77. PMID:15299376

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